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40 deflects down by a distance y(L) вF L33Y IA when a force F 6. 3 Antigen Uptake, Processing and Loading in the CD1 Pathway 146 Cellular Uptake of CD1-presented Antigens 146 Endosomal Processing of CD1-presented Antigens 147 Accessory Molecules for Endosomal Lipid Loading of CD1 148 Non-endosomal Loading of Lipids onto CD1 Molecules 149 Conclusions 150 Antigen Presenting Cellsв Ligands Recognized by T- and Toll-like Receptors 157 Naturally Processed Self-peptides of MHC Molecules Cheap Tadarise 60mg Harald Kropshofer and Sebastian Spindeldreher Introduction 159 Milestone Events 160 Nomenclature 160 Autologous Peptides 160 Endogenous Peptides 161 Natural Peptides Ex Vivo and In Vitro 161 Extra Electron Density Associated to MHC Cheap Tadarise 60mg 162 Acidic Peptide Elution Approach 163 First Natural Foreign Peptides on MHC Class II 165 First Natural Viral Epitopes on MHC Class I 165 Self-peptide Sequencing on MHC Class I the First Anchor Motifs 166 First Murine MHC Class II-associated Self-peptides Nested Sets 167 First Human MHC Class II-bound Self-peptides Hydrophobic Motifs 169 Progress in Cheap Tadarise 60mg Analysis of Natural Peptides 172 Edman Microsequencing 172 Electrospray Cheap Tadarise 60mg Tandem Mass Spectrometry 173 Automated Tandem Mass Spectrometry 175 MAPPs MHC-associated Peptide Proteomics 176 Natural Class II MHC-associated Peptides from Different Tissues and Cell-types 177 Peripheral Blood Mononuclear Cells 177 Myeloid Dendritic Cells 178 Medullary Thymic Epithelial Cells 179 Splenic APCs 181 Tumor Cells 181 Autoimmunity-related Epithelial Cells 182 The CLIP Story 183 CLIP in APCs Lacking HLA-DM 184 Flanking Residues and Self-release of CLIP 184 CLIP in Tetraspan Microdomains 185 Page 10 п6.
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