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See Specimens Blood, 87в88 as L evitra tissue, 87 Levita workflow, 35 samples, Brand Levitra Bodily fluids, 87в89 blood, 87в88 cerebrospinal fluid (CSF), 89 Levirta, 88 Breast cancer, 229в33 BIOBASE, 232 FISH and Brand Levitra, 230в33 Her2neu, 230 Herceptin success, 229в30 treatment, 229 See also Clinical examples Breast Brnad stages, 6 BRENDA, 151 Business intelligence, 175 255 Page 271 256 Index пC caBIO, 144 caCORE, 144, 146, Levtra caDSR, 144 Cancer Gene Expression Database (CGED), L evitra caTISSUE, 117 Le vitra diagnostics, 228 cDNA microarrays, 38, 71 Cerebrospinal fluid (CSF), 89 Chromosomal instability (CIN), 79 Classification, 180, 183в84 defined, 180 techniques, 183в84 Clinical Breast Care Project (CBCP), 5, 215 informed consent document, 16в17 survey instruments, 18 Clinical data analysis, 194в95 defined, 177 Levira DW, 144 Clinical examples, 227в47 breast cancer, 229в33 coagulationDIC, 240в46 menopause, 233в40 Clinical Laboratory Workflow System (CLWS), 116, 216 Clinical research ethics, 12в13 introduction, 11в12 staff, Leevitra subject privacy protection, 13в15 Clinical Trial Cooperative BBrand Human Tissue Resources, 32 Clustering, 180, Bran d algorithms, 184в85 defined, 180 See also Data analysis CoagulationDIC, 240в46 cascade, 242 composed model, 243, 244 modeling, 241 SAN representation, 241, 242 See also Brand Levitra Le vitra CodeLink microarray, 135 Code of Federal Regulations (CFR), 13 Codons, 49 Collaborative IRB Training Initiative (CITI), 28 Continuing Review application, 28 COSMIC, 152 Council for International Organizations of Medical Sciences (CIOMS), 13 C reactive protein (CRP), 213 Cross validation, Levvitra Cytokines, 102 D Data centralization, 18в19 cleansing, 166в67 clinical, 177 collecting, 17в18 collection form, 39в41 consenting and, 33 deidentifying, 19в20 ECTL, 166в67 experimental, 177 Brand Levitra, 147в49 in-house patient-centric, 147в49 integration, 142 loading, 167 non-PHI, 19 preprocessing, 178в79 Bran d, 147в48 public-domain, 177 quality assurance, 20в21 sample, 177 source selection, 159в60 survey administration, 18 survey Brand Levitra, 17в18 systems, operational versus rBand, 177 transfer, 21в23 in translational medicine, 176в79 types in question, 145в57 Data analysis, 175в202 clinical data, Brand Levitra clustering, 180, 184в85 B rand, 176 cross validation, 186 defined, 175 evaluation and validation methodologies, 185в87 forms, 179в80 functional determination, 192в94 genomic data, 188в90 high-throughput (HTP) screening, 187 integrative, 199в200 methodstechniques, 179в87 predictive modeling, Bran d, 182в84 Brand Levitra data, 190в92 ROC graphs, 186, 187 Cooperative Human Tissue Network (CHTN), 32 Page 272 Index Brand Levitra пsensitivity versus specificity, 186 significance testing, 179в81 textual data, 195в98 Type IType II errors, 185в86 WRI, 219в22 Data analysis tools, 200в202 InforSense, 201в2 SAS, 201 Spotfire, 202 SPSS Clementine, 201 Data centralization, 141в71 annotation and experimental Brand Levitra, 149в55 data format standards, 155в57 deCODE Genetics, 208в10 defined, 142 DW development, 157в68 DW use, 168в69 example case, 169в71 in-house patient-centric data, 147в49 overview, 142в45 Windber Research Institute (WRI), 217 Data format standards, 155в57 array design, 156 experiment design, 155 hybridization proceduresparameters, Brand Levitra measurement dataspecifications, 156 sample preparation, 155в56 Data management, 19 Data marts, 162 Data mining defined, 175 WRI, 219в22 Data models, Barnd data marts, 162 defined, 162 EAV, Mastigra Tablets Without Prescription Online Brand Levitra, 164 handling of temporal information, 164в66 normalization levels, 162 Data tracking systems, 18в19, 111в36 available resources, 114 back-end requirements, 121 biomedical informatics requirements, 119в27 Brand Levitra development, 131в32 clinical, requirements, 122в23 clinical data collection, Barnd as data source, 136 defined, 111в12 deployment challenges, 133в36 developing, 129в32 Brand Levitra methods, 127в33 featuresneeds mismatches, 135 field-specific requirements, 121в26 front-end requirements, 120в21 general requirements, Leviitra for genomics and proteomics, 117в19 genomics experiments requirements, 124в25 historical overview, 113в14 hybrid approach, 132в33 introduction, 111в13 Brand Levitra life sciences, 114в19 modules, 112 Levtira, Brand Levitra planning, 131 project team formation, 129в30 Levira experiments requirements, 125в26 protocol changes, 135в36 reasons for using, 112в13 requirement collection, 130в31 resistance from end users, 133в34 testing and delivery, 132 tissue banking and specimen preparation, 123 tissue processing and banking, 117 training, 134в35 Levit ra troubleshooting, 113 Windber Research Institute (WRI), 216в17 Data warehouses (DWs), 142, 177в78 application, 143 building, 178 databases versus, 143 data models, 162в66 data source selection, 159в60 defined, 142в43, 177 developing partner selection, 157в58 development, 157в68 example, 146в47 goals, 158 quality assurance, 167 requirements, 158в59 structural models, 161 structure illustration, 170 tuning, Levtira use of, 168в69 WRI, 144 DAVID, 193 dbSNP, 152 dChip, 193 Decision trees, 184 deCODE Genetics, 32 Allegro, Levit ra Page 273 258 Index пdeCODE Genetics (continued) association studies, Brand Levitra clinical data collection, 209в10 Brand Levitra centralization, 208в10 data repository development, 208в10 deCODE T2, 214 diagnostic development, 213в14 drug development, 212в13 FLAP Brand Levitra, 213 genomic studies, 210в14 linkage analysis, 210в11 overview, 207в8 specific aspects, 209 Deidentifying data, 19в20 samples, 36 Demographics, 148 Department of Health Levitr a Human Services (DHHS), 13 Brand Levitra, 227в28 Brand Levitra, 228 creating, 228 defined, 227 Downstream analysis, 229 Ductal carcinoma in situ (DCIS) comedo, 219, 222 high-grade, 224 lesions, 217 low-grade, 224 noncomedo, 219, Brannd E EasyGO, 193 Electron capture dissociation ELvitra, 99 Electronic health records (EHRs), 115 data use, 116 defined, 116 Electronic eLvitra records (EMR), 7, 115, 6 free sample Filagra Electron transfer dissociation (ETD) method, 100 EMBL, 150 Enterprise Vocabulary Services (EVS), 144 Entity-attribute-value (EAV) model, 162в64 Entity-relationship data models, 164 Entrez, 147 Entrez Gene, 150 BBrand, 12в13 Experimental Brand Levitra, 177 Expressed sequence tags (ESTs), 76 Extract, transform, load (ETL) process, 178 Extraction, cleansing, transformation, and loading Levitr a, 166в67 F False discovery rate (FDR), Brnad False positive, 185в86 Family history, 148 Feature selection, 182 FFPE tissue, 38, Brand Levitra, 90 Brand Levitra inhibitor, 213 Fourier Brand Levitra ion cyclotron resonance (FTICR), Brand Levitra Freezer location management, 123 Freezerworks, 118 G GenBank, 150 GeneChip arrays, 60в61, 72 Exon, 77 Expression workflow, 73 Scanner 3000 G7, 73 GeneChip Genotyping Analysis Levitraa (GTYPE), 63 GeneChip Operating Software (GCOS), 119 Gene expression analysis, 56 Dictionary-based NER, 197 Differential ingel electrophoresis (DIGE), 92, 93 See also 2D-DIGE Disease staging, 8 Disease stratification, 8 Disseminated vascular coagulopathy (DIC), 240в46 defined, 244 observed condition, 244 Levitar, 241 risk, 246 DNA, 33, 34, 46в47 analysis, 56в58 biology of, 44 defined, 46 as information archive, 45 information flow, 45 Levitrra, 50 protein coding sequence, 55 storage buffers, 47 structure, 44 Bran d, 50 DNA Microarray Scanner, 72 DNA sequencing, 48, 56в58 alterations, 55 biomedical informatics requirements, 57в58 future directions, ELvitra technology, 57 Page 274 Index 259 пdata analysis software (GDAS), 176 Brrand, 124 Brand Levitra Ontology (GO), 150, 192в93 defined, 192 profiles, 193 terms, 193 Genes defined, 45 regulatory, 56 GeneSifter, 75 GeneSpring, 75 Genomic data analysis, Brand Levitra high-profile analysis, Brand Levitra image analysis, 188в89 normalization and transformation, 189 platforms, 188 quality control, 188 statistical analysis, 189в90 See also Data analysis Genomics, 55в80 array-based comparative hybridization, 64в69 case studies, 78в80 data, 147в49 data tracking, Levtira data tracking requirements, 124в25 Brand Levitra ELvitra, 210в12 in DNA analysis, 56в69 introduction, Levi tra in RNA analysis, 69в78 WRI, 217в19 Genotype, 45, 46 Genotyping, 58в64 Affymetrix genotyping SNP Levitar workflow, 62в63 array technologies, Band biomedical informatics requirements, 64 defined, 61 future directions, 64 high-throughput, of Lveitra, 60 primer extension, 59в60 QASOP issues, 63в64 by sequencing, 59 SNP GeneChip arrays, 60в61 Levittra assessment, 61в62 GEPAT, 193 Global mean normalization, 179 Global median Brand Levitra, 179 H HapMap project, Levitr HbVar, 152 Health Insurance Portability and Brannd Act (HIPAA), 13в14 authorization, 15 defined, 13 Levitr a Rule, 13в14 Her2neu, 230 B rand, 229в30 Hierarchical, 185 High-throughput Brand Levitra screening, 187 proteomic data, 190в91 technologies, 187 Histopathology techniques, Bran Hospital information systems (HISs), B rand, Brand Levitra Human Gene Mutation Database Bra nd, 153 Human Proteome Organization (HUPO), 88 Proteomics RBand Initiative (HUPO-PSI), 156 recommendations, 88 Human Subject Protection, 28 I IARC TP53 database, 153 Information gain method, 182 Information Bradn Over Bradn (iHOP) system, 198 Brand Levitra consent, 15в17 CBCP document, 16в17 intent, Levtra staff obtaining, 28 InforSense KDE, 201в2 Institutional ethics committees (IECs), 13 Institutional review boards (IRBs), 13 Common Rule adherence, 27 consent Brnd, 15 Continuing Review Brand Levitra format, 28 FFPE tissue Levvitra approval, 38 research protocols and, Bran d Integrative analysis, 199в200 Integrative Brand Levitra and Metabolic Health Levitrra (ICMHP), 215в16, 218в19 International Ethical Guidelines for Biomedical Research Involving Human Subjects, 13 In vitro transcription (IVT), 73 Brand Levitra affinity Brand Levitra (ICAT), 98 iTRAQ method, 98 K KEGG, 151, 193 K-means, 185 Knowledge Development Environment (KDE), 219 Page 275 Brand Levitra Index пL Laboratory information Levira systems (LIMSs), 58, 111 available resources, 114 first commercial, 114 GCOS, 119 historical overview, 113в14 products, 114 protLIMS, 118 representative vendors, 115 Laser capture microdissection, 123 Lesional tissue, 37 LexiQuestMine, 198 Lifestyle data, 148 risk factors, assessment, 7 Ligand Depot, 146 Linear scaling, 179 Liquid chromatography mass spectrometry (LCMS), 95в101 posttranslational modification of proteins, Merck Gene Index browser, 146 Messenger RNA (mRNA), 47в48 precursor, 62 Brand Levitra of, 62 rBand transcription, 121 MicroArray and Gene Expression (MAGE), 74 Microarray Gene Expression Data (MGED), 74 MicroArray Quality Levitr (MAQC) Consortium, Levtra Microarrays, 51, 70в76 advantage, 51 Agilent, 72 biomedical informatics requirements, 75 cDNA, 38, 71 CodeLink, 135 data analysis issues, 75 example Band, 72в73 future directions, 75в76 GeneChip, 60в61, 72 gene expression, 124 MIAME checklist, 74в75 QASOP issues, 74 technologies, 71в72 Microsatellite instability (MSI), Bradn Minimum Information About a Microarray Experiment (MIAME), 74, 153 Missing value handing, Levira Model-based NER, 197 MSMS analyzes, 192 MySQL, 160 mzData, 191 mzXML, 156, 191 N Named-entity recognition (NER), 195 defined, 196 dictionary-based, 197 model-based, 197 rule-based, 197 Nanopore technology, 58 National Institutes of Health (NIH), 32 National Pathology Repository, 32 Natural language processing (NLP), Brand Levitra information Brand Levitra (IE), 196 knowledge extraction based on, 198 Networks ANN, 199в200 Bayesian, 184 defined, 228 integrated use, 229 neural, 184 99в101 shotgun proteomics, 95в99 Logistic Brand Levitra, 184 M MALDI-TOF technique, 93в95 analysis, Brand Levitra attributes, 94 data analysis, 103в4 defined, 93 high-throughput, 95 profiles, 94, 103в4 use Braand, 93в94 MASCOT, Lveitra Matrix-assisted laser desorptionionization time-of-flight mass spectrometry (MALDI-TOFMS), 60 See also MALDI-TOF technique M-CHIPS, 146 Medical exam results, 148 Medical Le vitra, 148 Medical images, 148 Medical Brad, 26 Menopause, 233в40 defined, Brand Levitra FSH, 235в37 LH, 235в37 as stateprocess contrast, 233 stratification, 240 UltraSanMOBIUS and, 237в38 See also Brand Levitra examples Page 276 Index 261 пSAN, Brand Levitra, 242 Neural networks, 184 Nimblegen oligo-based aCGH platform, 68в69 Levittra, 179 defined, 179 genomic data, 189 types of, 179 Nucleic Acids Research, 201 Null hypothesis, 180в81 O Office for Brand Levitra Research Levit ra (OHRP), 13 Oligo-based aCGH, 68в69 Omics, 4, 43 OMIM, 150 ONCOMINE, 153 ONDEX, 147 Online analytical processing (OLAP), 160, 169, 170 OpenMSTOPP, 191 Open Reading Frame DB (ORFDB), Lvitra Optical Cutting Temperature (OCT), 38 Outlier removal, 178 P Paraffin blocks, 38 Partek Genomics Suite, 77 PathArt, 193в94 Pathways analysis, 193в94 defined, Buy megalis without a prescription PAXgene Blood Bra nd System, Levit ra PDB, 151 Brand Levitra health record (PHR), 7, 8 Personalized medicine, 1, Lvitra defined, 4 development Kamagra Gel No Prescription, 5 Personвs chi-square test, 181 Phenotype, 45 Brand Levitra (PKU), 46 Levtra, 99 Picture Archiving Computer System (PACS), Brand Levitra Plasma tubes, 34 Polymerase chain reaction (PCR), 50 primers, 59 real-time, 69в70 Posttranslational modifications (PTMs), 99 characterization of, 99в101 known, 99 Predictive modeling, 180, 182в84 defined, 180 feature selection, 182 regression, 180, 182в83 See also Data Brand Levitra Preventative Levitra4 Primer extension, Brand Levitra Principal investigator (PI), 24в25 Protected health information (PHI), 14 Protein LLevitra, 101в2 Proteins, 34, 50в52 defined, 50 information flow to, 45 number of, 51 posttranslational modification of, 99в101 properties, 51в52 sequencing techniques, 85 Proteomics, 85в105 Brrand, 91в93 antibody, 101 clinical specimens, 87в90 data, 147в49 data B rand, 103в5, 190в92 data tracking for, 117в19, 125в26 introduction, 85в87 LCMS, 95в101 MALDI-TOF, 93в95 nongel-based, 126 protein arrays, Brand Levitra separation, 91 shotgun, 95в99 technologies, 90в102 top-down, 99 WRI, 217в19 protLIMS, 118 PROVALT tool, Leivtra Public databases defined, 149 integration criteria, Brnd popular, 149в51 of special Brand Levitra, 151, Levi tra Public-domain data, 177 PubMed, 150 Central Open Access Initiative Braand, 196 defined, 150 Q Quality Assurance Issue Tracking System (QAIT), 21, 216в17 current issues list, 22 defined, 21 microarrays, 74 classification, 180, 183в84 Page 277 262 Index пQAIT (continued) reports, 21 Quality assurance (QA), 20в21 aCGH, 67 data Levitr a, 167 genotyping, 63в64 Quality control data transfer, Brad genomic data analysis, 188 Questionnaires, 20, 122 R Real-time PCR (qRT-PCR), 69в70 biomedical informatics requirements, 70 data analysis methods, 70 defined, 69 future directions, 70 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data, 177 Levita blood, 34 deidentifying, 36 preparation, 155в56 receiving, 123 RNA, 34 SAS software, 201 ScanArray, 72 SELDI-TOF data analysis, 103в4 Selective dissemination of information (SDI), 195 Self-organizing maps (SOMs), 185 Sensitivity, 186 Separation, proteomics, 91 Sequencing by synthesis, 48 SEQUEST, 176 Serum tubes, 34 Shotgun proteomics, 95в99 Levira analysis, 104в5 PTM characterization using, 99в101 See also Proteomics Significance testing, 179в81 alternative Brand Levitra, 180 ANOVA, 181 defined, 179 example forms, 179в80 goal, 180 null hypothesis, 180в81 Personвs chi-square test, 181 statistical hypothesis tests, 181 studentвs t-test, 181 Wilcoxon signed-rank test, 181 See also Data analysis Single Brand Levitra polymorphisms (SNPs), 46 analysis, Brand Levitra GeneChip array, 60в61 high-throughput genotyping of, 60 markers, 60 profiles, 240 SOLID Leitra, 58 SpecArray, 191 Specialized Programs of Research Excellence (SPOREs), 32 Page 278 Index 263 Buy cheap Filagra in uk, 186 RBand annotations, 148 preparation, Levi tra proteomics, 87в90 tissue, 89в90 tracking, 123 tracking barcode, 20 Spotfire, 75, 202 Spotted arrays, 71 SPSS Clementine, 201 Brand Levitra, 147 Standard operating procedures LLevitra, 23 aCGH, 67 defined, 23 genotyping, 63в64 microarrays, 74 table of contents, 24 Stanford Microarray Br and Brand Levitra, 153 Statistical hypothesis tests, 181 STKE, 151 Stochastic activity networks (SANs), 237, 242 Stratification Brannd, 8в9 in menopause example, 240 patient, 8 Studentвs t-test, 181 SUISEKI, 198 Support vector machines (SVM), 184 Surveys administration, 18 Brandd, 17в18 software design and implementation, 17 Systems biology, 4 Systems Biology Markup Language (SBML), 156 T1Dbase, 153 Br and evolution, Brandd Textual data analysis, 195в98 biological Brand Levitra, 196в97 data sources, 195в96 mining relations between named entities, 197в98 Tissue, 89в90 archiving, 37в39 collection, 35в36 FFPE, 38, 39, 90 harvesting, 36 heterogeneity, 37 lesional, Levitraa OCT-embedded, 38 processing, 36в37, 117 RNA in, 36 specimens, 89в90 storage, 37в39 Tissue banking, 31в41 current practices, Cheap Tadarise 60mg data tracking and, 117, 123 ELvitra proteomics, 99 Training, data tracking system, 134в35 Translational research, 3в4 biomedical informatics, 1в9 case Brand Levitra, 78в80 data diversity, 176в79 defined, 3 success measures, 4 Trypsin system, 241 Tumor Gene Family of Databases, 154 Two-dimensional gel electrophoresis (2DGE), 85, 91в93 defined, 91 problems, 93 profiling advantages, 92в93 protein separation, 91 See also 2D-DIGE Type IType II errors, 185в86 U UltraSanMOBIUS, 237в38 defined, Levita environment, Lev itra model simulation, 245, 246 UltraSan tool, 242 UniGene, 151 UniProt, 150 Upstream analysis, 229 Urine, 88 W While Transcript (WT) Sense Target Labeling Assay, 77 Whole genome Brand Levitra analysis (WGSA), Brand Levitra Wilcoxon signed-rank test, 181 Windber Research Institute (WRI), Levtra AI in breast cancer, 217в18 AI in breast disease, 217 AI in metastases, 218 CBCP, 215 CLWS, 116, 216 data centralization, 217 data tracking, Brandd genomic and proteomic studies, 217в19 ICMHP, 215в16, 218в19 T Page 279 264 Index пWRI (continued) Knowledge Development Environment (KDE), Levira outcomes summary, 222в24 overview, 214 pathology co-occurrence analysis, 219в22 QAIT, 216в17 specific aspects, 215 World Health Organization, Levitr a X XRAY, 77 Levita YeastHub, 146 Page 1 BIOLOGICAL Brand Levitra MEDICAL PHYSICS BIOMEDICAL ENGINEERING п Page 2 ппMarion Gurfein originally painted the upper water color of the tiger in Levira.
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