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See Specimens Blood, 87в88 as L evitra tissue, 87 Levita workflow, 35 samples, Brand Levitra Bodily fluids, 87в89 blood, 87в88 cerebrospinal fluid (CSF), 89 Levirta, 88 Breast cancer, 229в33 BIOBASE, 232 FISH and Brand Levitra, 230в33 Her2neu, 230 Herceptin success, 229в30 treatment, 229 See also Clinical examples Breast Brnad stages, 6 BRENDA, 151 Business intelligence, 175 255 Page 271 256 Index пC caBIO, 144 caCORE, 144, 146, Levtra caDSR, 144 Cancer Gene Expression Database (CGED), L evitra caTISSUE, 117 Le vitra diagnostics, 228 cDNA microarrays, 38, 71 Cerebrospinal fluid (CSF), 89 Chromosomal instability (CIN), 79 Classification, 180, 183в84 defined, 180 techniques, 183в84 Clinical Breast Care Project (CBCP), 5, 215 informed consent document, 16в17 survey instruments, 18 Clinical data analysis, 194в95 defined, 177 Levira DW, 144 Clinical examples, 227в47 breast cancer, 229в33 coagulationDIC, 240в46 menopause, 233в40 Clinical Laboratory Workflow System (CLWS), 116, 216 Clinical research ethics, 12в13 introduction, 11в12 staff, Leevitra subject privacy protection, 13в15 Clinical Trial Cooperative BBrand Human Tissue Resources, 32 Clustering, 180, Bran d algorithms, 184в85 defined, 180 See also Data analysis CoagulationDIC, 240в46 cascade, 242 composed model, 243, 244 modeling, 241 SAN representation, 241, 242 See also Brand Levitra Le vitra CodeLink microarray, 135 Code of Federal Regulations (CFR), 13 Codons, 49 Collaborative IRB Training Initiative (CITI), 28 Continuing Review application, 28 COSMIC, 152 Council for International Organizations of Medical Sciences (CIOMS), 13 C reactive protein (CRP), 213 Cross validation, Levvitra Cytokines, 102 D Data centralization, 18в19 cleansing, 166в67 clinical, 177 collecting, 17в18 collection form, 39в41 consenting and, 33 deidentifying, 19в20 ECTL, 166в67 experimental, 177 Brand Levitra, 147в49 in-house patient-centric, 147в49 integration, 142 loading, 167 non-PHI, 19 preprocessing, 178в79 Bran d, 147в48 public-domain, 177 quality assurance, 20в21 sample, 177 source selection, 159в60 survey administration, 18 survey Brand Levitra, 17в18 systems, operational versus rBand, 177 transfer, 21в23 in translational medicine, 176в79 types in question, 145в57 Data analysis, 175в202 clinical data, Brand Levitra clustering, 180, 184в85 B rand, 176 cross validation, 186 defined, 175 evaluation and validation methodologies, 185в87 forms, 179в80 functional determination, 192в94 genomic data, 188в90 high-throughput (HTP) screening, 187 integrative, 199в200 methodstechniques, 179в87 predictive modeling, Bran d, 182в84 Brand Levitra data, 190в92 ROC graphs, 186, 187 Cooperative Human Tissue Network (CHTN), 32 Page 272 Index Brand Levitra пsensitivity versus specificity, 186 significance testing, 179в81 textual data, 195в98 Type IType II errors, 185в86 WRI, 219в22 Data analysis tools, 200в202 InforSense, 201в2 SAS, 201 Spotfire, 202 SPSS Clementine, 201 Data centralization, 141в71 annotation and experimental Brand Levitra, 149в55 data format standards, 155в57 deCODE Genetics, 208в10 defined, 142 DW development, 157в68 DW use, 168в69 example case, 169в71 in-house patient-centric data, 147в49 overview, 142в45 Windber Research Institute (WRI), 217 Data format standards, 155в57 array design, 156 experiment design, 155 hybridization proceduresparameters, Brand Levitra measurement dataspecifications, 156 sample preparation, 155в56 Data management, 19 Data marts, 162 Data mining defined, 175 WRI, 219в22 Data models, Barnd data marts, 162 defined, 162 EAV, Mastigra Tablets Without Prescription Online Brand Levitra, 164 handling of temporal information, 164в66 normalization levels, 162 Data tracking systems, 18в19, 111в36 available resources, 114 back-end requirements, 121 biomedical informatics requirements, 119в27 Brand Levitra development, 131в32 clinical, requirements, 122в23 clinical data collection, Barnd as data source, 136 defined, 111в12 deployment challenges, 133в36 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development, 157в68 example, 146в47 goals, 158 quality assurance, 167 requirements, 158в59 structural models, 161 structure illustration, 170 tuning, Levtira use of, 168в69 WRI, 144 DAVID, 193 dbSNP, 152 dChip, 193 Decision trees, 184 deCODE Genetics, 32 Allegro, Levit ra Page 273 258 Index пdeCODE Genetics (continued) association studies, Brand Levitra clinical data collection, 209в10 Brand Levitra centralization, 208в10 data repository development, 208в10 deCODE T2, 214 diagnostic development, 213в14 drug development, 212в13 FLAP Brand Levitra, 213 genomic studies, 210в14 linkage analysis, 210в11 overview, 207в8 specific aspects, 209 Deidentifying data, 19в20 samples, 36 Demographics, 148 Department of Health Levitr a Human Services (DHHS), 13 Brand Levitra, 227в28 Brand Levitra, 228 creating, 228 defined, 227 Downstream analysis, 229 Ductal carcinoma in situ (DCIS) comedo, 219, 222 high-grade, 224 lesions, 217 low-grade, 224 noncomedo, 219, Brannd E EasyGO, 193 Electron capture dissociation ELvitra, 99 Electronic health records (EHRs), 115 data use, 116 defined, 116 Electronic eLvitra records (EMR), 7, 115, 6 free sample Filagra Electron transfer dissociation (ETD) method, 100 EMBL, 150 Enterprise Vocabulary Services (EVS), 144 Entity-attribute-value (EAV) model, 162в64 Entity-relationship data models, 164 Entrez, 147 Entrez Gene, 150 BBrand, 12в13 Experimental Brand Levitra, 177 Expressed sequence tags (ESTs), 76 Extract, transform, load (ETL) process, 178 Extraction, cleansing, transformation, and loading Levitr a, 166в67 F False discovery rate (FDR), Brnad False positive, 185в86 Family history, 148 Feature selection, 182 FFPE tissue, 38, Brand Levitra, 90 Brand Levitra inhibitor, 213 Fourier Brand Levitra ion cyclotron resonance (FTICR), Brand Levitra Freezer location management, 123 Freezerworks, 118 G GenBank, 150 GeneChip arrays, 60в61, 72 Exon, 77 Expression workflow, 73 Scanner 3000 G7, 73 GeneChip Genotyping Analysis Levitraa (GTYPE), 63 GeneChip Operating Software (GCOS), 119 Gene expression analysis, 56 Dictionary-based NER, 197 Differential ingel electrophoresis (DIGE), 92, 93 See also 2D-DIGE Disease staging, 8 Disease stratification, 8 Disseminated vascular coagulopathy (DIC), 240в46 defined, 244 observed condition, 244 Levitar, 241 risk, 246 DNA, 33, 34, 46в47 analysis, 56в58 biology of, 44 defined, 46 as information archive, 45 information flow, 45 Levitrra, 50 protein coding sequence, 55 storage buffers, 47 structure, 44 Bran d, 50 DNA Microarray Scanner, 72 DNA sequencing, 48, 56в58 alterations, 55 biomedical informatics requirements, 57в58 future directions, ELvitra technology, 57 Page 274 Index 259 пdata analysis software (GDAS), 176 Brrand, 124 Brand Levitra Ontology (GO), 150, 192в93 defined, 192 profiles, 193 terms, 193 Genes defined, 45 regulatory, 56 GeneSifter, 75 GeneSpring, 75 Genomic data analysis, Brand Levitra high-profile analysis, Brand Levitra image analysis, 188в89 normalization and transformation, 189 platforms, 188 quality control, 188 statistical analysis, 189в90 See also Data analysis Genomics, 55в80 array-based comparative hybridization, 64в69 case studies, 78в80 data, 147в49 data tracking, Levtira data tracking requirements, 124в25 Brand Levitra ELvitra, 210в12 in DNA analysis, 56в69 introduction, Levi tra in RNA analysis, 69в78 WRI, 217в19 Genotype, 45, 46 Genotyping, 58в64 Affymetrix genotyping SNP Levitar workflow, 62в63 array technologies, Band biomedical informatics requirements, 64 defined, 61 future directions, 64 high-throughput, of Lveitra, 60 primer extension, 59в60 QASOP issues, 63в64 by sequencing, 59 SNP GeneChip arrays, 60в61 Levittra assessment, 61в62 GEPAT, 193 Global mean normalization, 179 Global median Brand Levitra, 179 H HapMap project, Levitr HbVar, 152 Health Insurance Portability and Brannd Act (HIPAA), 13в14 authorization, 15 defined, 13 Levitr a Rule, 13в14 Her2neu, 230 B rand, 229в30 Hierarchical, 185 High-throughput Brand Levitra screening, 187 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example Band, 72в73 future directions, 75в76 GeneChip, 60в61, 72 gene expression, 124 MIAME checklist, 74в75 QASOP issues, 74 technologies, 71в72 Microsatellite instability (MSI), Bradn Minimum Information About a Microarray Experiment (MIAME), 74, 153 Missing value handing, Levira Model-based NER, 197 MSMS analyzes, 192 MySQL, 160 mzData, 191 mzXML, 156, 191 N Named-entity recognition (NER), 195 defined, 196 dictionary-based, 197 model-based, 197 rule-based, 197 Nanopore technology, 58 National Institutes of Health (NIH), 32 National Pathology Repository, 32 Natural language processing (NLP), Brand Levitra information Brand Levitra (IE), 196 knowledge extraction based on, 198 Networks ANN, 199в200 Bayesian, 184 defined, 228 integrated use, 229 neural, 184 99в101 shotgun proteomics, 95в99 Logistic Brand Levitra, 184 M MALDI-TOF technique, 93в95 analysis, Brand Levitra attributes, 94 data analysis, 103в4 defined, 93 high-throughput, 95 profiles, 94, 103в4 use Braand, 93в94 MASCOT, Lveitra Matrix-assisted laser desorptionionization time-of-flight mass spectrometry (MALDI-TOFMS), 60 See also MALDI-TOF technique M-CHIPS, 146 Medical exam results, 148 Medical Le vitra, 148 Medical images, 148 Medical Brad, 26 Menopause, 233в40 defined, Brand Levitra FSH, 235в37 LH, 235в37 as stateprocess contrast, 233 stratification, 240 UltraSanMOBIUS and, 237в38 See also Brand Levitra examples Page 276 Index 261 пSAN, Brand Levitra, 242 Neural networks, 184 Nimblegen oligo-based aCGH platform, 68в69 Levittra, 179 defined, 179 genomic data, 189 types of, 179 Nucleic Acids Research, 201 Null hypothesis, 180в81 O Office for Brand Levitra Research Levit ra (OHRP), 13 Oligo-based aCGH, 68в69 Omics, 4, 43 OMIM, 150 ONCOMINE, 153 ONDEX, 147 Online analytical processing (OLAP), 160, 169, 170 OpenMSTOPP, 191 Open Reading Frame DB (ORFDB), Lvitra Optical Cutting Temperature (OCT), 38 Outlier removal, 178 P Paraffin blocks, 38 Partek Genomics Suite, 77 PathArt, 193в94 Pathways analysis, 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clinical specimens, 87в90 data, 147в49 data B rand, 103в5, 190в92 data tracking for, 117в19, 125в26 introduction, 85в87 LCMS, 95в101 MALDI-TOF, 93в95 nongel-based, 126 protein arrays, Brand Levitra separation, 91 shotgun, 95в99 technologies, 90в102 top-down, 99 WRI, 217в19 protLIMS, 118 PROVALT tool, Leivtra Public databases defined, 149 integration criteria, Brnd popular, 149в51 of special Brand Levitra, 151, Levi tra Public-domain data, 177 PubMed, 150 Central Open Access Initiative Braand, 196 defined, 150 Q Quality Assurance Issue Tracking System (QAIT), 21, 216в17 current issues list, 22 defined, 21 microarrays, 74 classification, 180, 183в84 Page 277 262 Index пQAIT (continued) reports, 21 Quality assurance (QA), 20в21 aCGH, 67 data Levitr a, 167 genotyping, 63в64 Quality control data transfer, Brad genomic data analysis, 188 Questionnaires, 20, 122 R Real-time PCR (qRT-PCR), 69в70 biomedical informatics requirements, 70 data analysis methods, 70 defined, 69 future directions, 70 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