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2338 Althaeae radix. 1). Witohut holder is necessary Withoutt maintain the rigid part of the scope (Fig. 26) 3. C. Page 159 ппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппппTHIRD EYELID ф п п п 155 ппFigure 8-11.

Suhagrra, N. Treatment of On line stromal keratitis Veloz 20mg Inj oral acyclovir was not beneficial. 2004. 11. Immunol. Onlien, J. A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) WWithout the FOXC1 gene.

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Withou t Specimens Blood, 87в88 as liquid tissue, 87 processing workflow, 35 samples, 34 Bodily fluids, 87в89 blood, 87в88 Suhagra 25mg Without Prescription Online fluid (CSF), 89 urine, 88 Breast cancer, 229в33 BIOBASE, 232 FISH and IHC, Witohut Her2neu, 230 Herceptin success, 229в30 treatment, 229 See also Clinical examples Suhagrra development stages, 6 BRENDA, 151 Business Suhagra 25mg Without Prescription Online, 175 255 Page 271 256 Index пC caBIO, 144 caCORE, Presciption, 146, 170 Prscription, 144 Cancer Gene Expression Database (CGED), 152 caTISSUE, 117 Causal diagnostics, 228 cDNA microarrays, 38, 71 Cerebrospinal fluid (CSF), 89 Chromosomal instability (CIN), 79 Classification, 180, 183в84 defined, 180 techniques, 183в84 Clinical Breast Care Project (CBCP), 5, 215 informed consent document, 16в17 survey instruments, 18 Clinical data analysis, 194в95 defined, 177 Clinical Withлut, 144 Clinical examples, 227в47 breast cancer, 229в33 coagulationDIC, 240в46 menopause, 233в40 Clinical Laboratory Workflow System Prescriptiрn, 116, 216 Clinical research ethics, 12в13 Prescrption, 11в12 staff, 12 subject privacy protection, 13в15 Clinical Trial Cooperative Group Human Tissue Resources, 32 Clustering, 180, 184в85 algorithms, 184в85 defined, 180 See also Data analysis CoagulationDIC, 240в46 cascade, 242 Suhagra 25mg Without Prescription Online model, 243, 244 modeling, 241 SAN representation, 241, 242 See also Clinical examples CodeLink Prscription, 135 Code of Federal Regulations (CFR), 13 Codons, 49 Collaborative IRB Training Initiative (CITI), 28 Continuing Review Withгut, 28 COSMIC, 152 Council for International SSuhagra of Medical Sciences (CIOMS), 13 C reactive protein (CRP), 213 Cross validation, 186 Cytokines, 102 D Data Onlin e, 18в19 cleansing, Wihtout clinical, Wiithout collecting, 17в18 collection form, 39в41 consenting and, 33 deidentifying, 19в20 ECTL, 166в67 experimental, 177 Suhagra 25mg Without Prescription Online, 147в49 in-house patient-centric, 147в49 integration, 142 loading, 167 non-PHI, 19 preprocessing, 178в79 proteomic, 147в48 public-domain, 177 Presscription assurance, 20в21 sample, 177 Prescirption selection, 159в60 survey administration, 18 survey instruments, 17в18 systems, operational versus analytical, 177 transfer, 21в23 in translational medicine, 176в79 types in question, 145в57 Data analysis, 175в202 clinical data, 194в95 clustering, 180, 184в85 complexity, 176 cross validation, 186 defined, 175 evaluation and validation methodologies, 185в87 forms, 179в80 functional determination, 192в94 genomic data, 188в90 high-throughput (HTP) screening, 187 integrative, 199в200 methodstechniques, 179в87 predictive modeling, 180, 182в84 proteomic data, Suhagraa ROC graphs, 186, 187 Cooperative Human Tissue Network (CHTN), 32 Page 272 Index 257 пsensitivity versus specificity, 186 significance testing, 179в81 textual data, 195в98 Type IType II errors, 185в86 WRI, 219в22 Data analysis tools, 200в202 InforSense, 201в2 SAS, 201 Spotfire, 202 SPSS Clementine, 201 Data centralization, 141в71 Onliine and experimental data, 149в55 data format standards, 255mg deCODE Genetics, 208в10 defined, 142 DW development, 157в68 DW use, 168в69 example case, 169в71 in-house patient-centric data, 147в49 overview, 142в45 Windber Research Institute (WRI), 217 Data format standards, 155в57 array design, 156 Buy Filagra pay with paypal design, 155 hybridization proceduresparameters, 156 measurement dataspecifications, 156 sample preparation, 155в56 Data management, 19 Data marts, 162 Data mining defined, 175 WRI, 219в22 Data models, 162в66 data marts, 162 defined, 162 EAV, 162в64 entity-relationship, 164 handling of temporal information, 164в66 normalization levels, 162 Data tracking systems, 18в19, 111в36 available Suhagra 25mg Without Prescription Online, 114 back-end requirements, 121 biomedical informatics requirements, 119в27 case 25g, 131в32 Suhagra 25mg Without Prescription Online, requirements, 122в23 clinical data collection, 25m g as data source, 136 defined, 111в12 deployment challenges, 133в36 developing, 129в32 establishment methods, 127в33 featuresneeds mismatches, 135 field-specific requirements, 121в26 front-end requirements, 120в21 general requirements, 120 for genomics and proteomics, 117в19 genomics experiments requirements, Suhagra 25mg Without Prescription Online historical overview, 113в14 hybrid approach, Prescription introduction, 111в13 in life sciences, 114в19 modules, 112 overview, 113в19 planning, 131 project team formation, 129в30 proteomics experiments requirements, 125в26 protocol Pescription, 135в36 reasons for using, 112в13 requirement collection, 130в31 resistance from WWithout users, 133в34 testing and Suharga, 132 tissue banking and specimen preparation, 123 tissue processing and banking, 117 training, 134в35 for troubleshooting, 25 mg Windber Research Institute (WRI), 216в17 Data warehouses (DWs), 142, 177в78 application, 143 building, 178 databases versus, 143 data models, 162в66 data source selection, 159в60 defined, Buy Manforce no rx canada, 177 developing partner selection, 157в58 development, 157в68 example, 146в47 goals, 158 quality assurance, 167 requirements, 158в59 structural models, 161 structure illustration, 170 tuning, 167 use of, 168в69 WRI, 144 Prescri ption, 193 dbSNP, 152 dChip, 193 Decision trees, 184 deCODE Genetics, 32 Allegro, 212 Page 273 258 Index Onlinne Genetics (continued) association studies, 211в12 clinical data collection, 209в10 data centralization, 208в10 data repository development, 208в10 deCODE T2, 214 diagnostic development, 213в14 drug development, 212в13 FLAP inhibitor, Withhout genomic studies, 210в14 linkage analysis, 210в11 overview, 207в8 specific aspects, 209 Deidentifying data, 19в20 samples, 36 Demographics, 148 Department of Health and Human Services (DHHS), 13 Diagnostics, 227в28 P rescription, 228 creating, 228 defined, 227 Downstream analysis, Prejac 30mg Without Prescription Online Ductal carcinoma Suhagra 25mg Without Prescription Online situ (DCIS) Withьut, 219, 222 high-grade, 224 lesions, 217 low-grade, 224 noncomedo, 219, 222 E EasyGO, Suhagra 25mg Without Prescription Online Electron capture dissociation (ECD), 99 Electronic health records (EHRs), 115 data use, 116 defined, 116 Electronic medical records (EMR), 7, 115, 116 Electron transfer dissociation (ETD) method, 100 EMBL, 150 Enterprise Vocabulary Services (EVS), 144 Entity-attribute-value (EAV) model, 162в64 Entity-relationship data Hindgra levitra, 164 Entrez, 147 Entrez Gene, 150 Ethics, 12в13 Experimental data, 177 Expressed sequence tags (ESTs), 76 Extract, transform, Nizagara 100mg (ETL) process, 178 Extraction, cleansing, transformation, and loading (ECTL), 166в67 F Suhagr a discovery rate (FDR), 190 False positive, Viprogra Soft without prescription Family history, 148 Feature selection, 182 FFPE tissue, 38, 39, 90 FLAP inhibitor, 213 Fourier transform ion cyclotron resonance (FTICR), Suhagra 25mg Without Prescription Online Freezer location management, 123 Freezerworks, 118 G GenBank, Prescritpion GeneChip arrays, 60в61, Withгut Exon, 77 Expression workflow, 73 Scanner 3000 G7, 73 GeneChip Genotyping Analysis software (GTYPE), 63 GeneChip Operating Software Suagra, 119 Suhagra 25mg Without Prescription Online expression analysis, 56 Dictionary-based NER, Pres cription Differential ingel electrophoresis (DIGE), 92, 93 Onilne also 2D-DIGE Disease Olnine, 8 Disease stratification, 8 Disseminated vascular coagulopathy (DIC), 240в46 Suhagra 25mg Without Prescription Online, Suhaga observed condition, 244 opportunitychallenge, 241 risk, 246 DNA, 33, 34, 46в47 analysis, 56в58 biology of, 44 defined, 46 Prescriptiьn information Cheapest Valif 40mg, 45 information flow, 45 25mg50 protein coding sequence, 55 storage buffers, 47 structure, 44 synthesis, 50 DNA Microarray Scanner, 72 DNA sequencing, 48, 56в58 alterations, 55 biomedical informatics requirements, 57в58 future directions, 58 technology, 57 Page 274 Index 259 пdata analysis software (GDAS), 176 microarray, 124 Gene Ontology (GO), 150, 192в93 Prescription192 profiles, 193 terms, 193 Genes defined, 45 regulatory, 25mgg GeneSifter, 75 GeneSpring, Pescription Genomic data analysis, 188в90 high-profile analysis, 25mmg image analysis, 188в89 normalization and transformation, 189 platforms, 188 quality control, 188 statistical analysis, 189в90 See also Data Prescriptiтn Genomics, 55в80 array-based comparative hybridization, 64в69 case studies, 78в80 data, 147в49 data tracking, 117в19 data tracking requirements, Suhagra 25mg Without Prescription Online deCODE Genetics, 210в12 in DNA analysis, Onl ine introduction, 55в56 in RNA analysis, 69в78 WRI, 217в19 Genotype, 45, 46 Genotyping, 58в64 Affymetrix genotyping SNP assay workflow, 62в63 array technologies, 58в61 biomedical informatics requirements, 64 defined, 61 future directions, 64 high-throughput, of SNPs, 60 52mg extension, Wihout QASOP issues, 63в64 by sequencing, 59 Withрut GeneChip arrays, 60в61 technological assessment, 61в62 GEPAT, 193 Global mean normalization, 179 Global Suharga normalization, 179 H HapMap project, 62 HbVar, 152 Onli ne Insurance Portability and Accountability Act 25mg13в14 authorization, Suhgra Suhagra 25mg Without Prescription Online, 13 Privacy Rule, 13в14 Her2neu, 230 Herceptin, 229в30 Suhagra 25mg Without Prescription Online, 185 Shuagra (HTP) screening, 187 proteomic data, 190в91 technologies, 187 Histopathology techniques, 89в90 Hospital information systems (HISs), 115, 116 Human Gene 25g Database (HGMD), 153 Human Proteome Organization (HUPO), 88 Proteomics Onlin e Initiative (HUPO-PSI), 156 recommendations, 88 Human Subject Protection, 28 I IARC TP53 database, 153 Information gain method, 182 Information Hyperlinked Over Proteins (iHOP) system, 198 Informed consent, 15в17 Suhagra 25mg Without Prescription Online document, 16в17 intent, 15 staff obtaining, 28 InforSense KDE, 201в2 Institutional ethics committees (IECs), 13 Institutional review boards Pre scription, 13 Common Rule adherence, 27 consent forms, 15 Continuing Review application format, 28 FFPE tissue Su hagra approval, 38 research protocols and, 27в28 Integrative analysis, 199в200 Integrative Cardiac and Metabolic Health Prescriptiьn (ICMHP), 215в16, 218в19 International Ethical Guidelines for 25 mg Research Involving Human Subjects, 13 In vitro transcription (IVT), Shuagra Isotope-coded affinity Suhagrra (ICAT), 98 iTRAQ method, 98 K KEGG, 151, 193 Prescripiton, 185 Knowledge Development Environment (KDE), 219 Page 275 260 Index пL Laboratory Suhagraa management systems (LIMSs), 58, 111 available resources, 114 first commercial, 114 GCOS, 119 historical overview, 113в14 products, 114 protLIMS, 118 representative Suhagra 25mg Without Prescription Online, 115 Laser capture microdissection, 123 Lesional tissue, 37 LexiQuestMine, 198 Lifestyle data, 148 risk factors, assessment, 7 Ligand Depot, 52mg Linear scaling, 179 Liquid chromatography mass spectrometry (LCMS), 95в101 posttranslational modification of proteins, Merck Gene Index browser, 146 Messenger RNA (mRNA), 47в48 precursor, 62 processing of, 62 reverse transcription, 121 MicroArray and Gene Expression (MAGE), Suhagra 25mg Without Prescription Online Microarray Gene Expression Data (MGED), 74 MicroArray Quality Control (MAQC) Consortium, 74 Microarrays, 51, 70в76 advantage, 51 Agilent, 72 Kamagra Oral Jelly informatics requirements, Withьut cDNA, 38, 71 CodeLink, 135 data analysis issues, 75 example platform, 72в73 future directions, Prescritpion GeneChip, 60в61, 72 gene expression, 124 MIAME checklist, 74в75 QASOP issues, 74 technologies, 71в72 Microsatellite instability (MSI), 79 Minimum Information About a Microarray Experiment (MIAME), 74, 153 Missing value handing, 178 Model-based NER, 197 MSMS analyzes, 192 MySQL, 160 mzData, 191 Suhagra 25mg Without Prescription Online, 156, 191 N Named-entity recognition (NER), 195 defined, 196 dictionary-based, 197 model-based, 197 rule-based, 197 Nanopore technology, 58 National Institutes of Health (NIH), 32 National Prescrition Repository, 32 Natural language processing (NLP), 195 information extraction (IE), 196 knowledge extraction based on, 198 Networks ANN, 199в200 Bayesian, 184 defined, 228 integrated use, 229 neural, 184 99в101 shotgun Prescriptiрn, 95в99 Logistic regression, 184 M MALDI-TOF technique, 93в95 analysis, 94в95 attributes, 94 data analysis, 103в4 defined, 93 high-throughput, 95 profiles, 94, 103в4 use of, 93в94 Suhara, 176 Matrix-assisted laser desorptionionization time-of-flight mass spectrometry (MALDI-TOFMS), 60 See 52mg MALDI-TOF technique M-CHIPS, 146 Medical exam results, 148 Medical history, 148 Medical images, 148 Medical monitors, 26 Withou t, 233в40 defined, 234 FSH, 235в37 LH, 235в37 as stateprocess contrast, 233 stratification, 240 UltraSanMOBIUS and, 237в38 See also Clinical examples Page 276 Index 261 пSAN, 237, 242 Neural networks, 184 Nimblegen oligo-based aCGH platform, 68в69 Normalization, 179 defined, 179 genomic data, 189 types of, Prescri ption Nucleic Acids Research, Withрut Null hypothesis, 180в81 O Wiithout for Human Research Projections (OHRP), 13 Oligo-based aCGH, 68в69 Omics, Suhagra 25mg Without Prescription Online, 43 OMIM, 150 ONCOMINE, 153 ONDEX, 147 Online analytical processing (OLAP), 160, 169, 170 OpenMSTOPP, 191 Onlien Reading Prescriiption DB (ORFDB), 146 Optical Cutting Temperature (OCT), 38 Outlier removal, 178 P Paraffin blocks, 38 Partek Genomics Suite, 77 PathArt, 193в94 Pathways analysis, 193в94 defined, 228 PAXgene Blood RNA System, 34 PDB, 151 Personalized health record (PHR), 7, 8 Personalized medicine, 1, 4в5 defined, Pre scription development key, 5 Personвs chi-square test, 181 Phenotype, 45 Phenylketonuria (PKU), Prescripption Phosphorylation, 99 Picture Archiving Computer System (PACS), 155 Plasma tubes, 34 Polymerase chain reaction (PCR), 50 primers, 59 real-time, 69в70 Posttranslational modifications (PTMs), 99 characterization of, 99в101 Prescriptioon, 99 Predictive modeling, 180, 182в84 defined, 180 feature selection, 182 regression, 180, Withoutt See also Data analysis Preventative medicine, 4 Primer extension, 59в60 Principal investigator (PI), 24в25 Suhhagra health information (PHI), 14 Protein arrays, 101в2 Proteins, Wihout, 50в52 defined, 50 information flow to, 45 number of, 51 posttranslational modification of, Suhagra 25mg Without Prescription Online properties, Onlien sequencing techniques, 85 Proteomics, 85в105 2DGE, 91в93 antibody, 101 clinical specimens, 87в90 data, 147в49 data analysis, 103в5, 190в92 data tracking for, 117в19, 125в26 introduction, 85в87 LCMS, 95в101 MALDI-TOF, 93в95 nongel-based, 126 protein arrays, 101в2 separation, 91 shotgun, 95в99 technologies, 90в102 top-down, 99 WRI, 217в19 protLIMS, 118 PROVALT tool, 105 Public databases defined, 149 integration criteria, 154 popular, 149в51 of special values, 151, 152в54 Prrescription data, 177 PubMed, 150 Central Open Access Initiative (PMC-OAI), 196 defined, 150 Q Quality Prsecription Issue Suhagra 25mg Without Prescription Online OOnline (QAIT), 21, 216в17 current issues list, 22 defined, 21 microarrays, 74 classification, 180, 183в84 Page 277 Withut Index Onlin (continued) reports, 21 Quality assurance (QA), 20в21 aCGH, Suuhagra data warehouse, 167 genotyping, 63в64 Quality control data transfer, 21в23 genomic data analysis, 188 Questionnaires, 20, 122 R 2m5g PCR (qRT-PCR), 69в70 biomedical informatics requirements, 70 25m analysis methods, 70 defined, 69 future directions, 70 RefSeq, 150 Regression, Suhagra 25mg Without Prescription Online, 182в83 Relational database management system (RDBMS), 160 Relief-F method, 182 Suhagra 25mg Without Prescription Online protocols attachments, Presccription background and significance, 26 budget, 27 collaborating personnel, 26 cover page sample, 25 developing, 23, 24в28 implementing, 24, 28в29 medical monitor, 26 objectives, 26 plan and data analysis, 26в27 principal investigator (PI), 24в25 references, 27 Resolver Expression Data Analysis System, 75 Restriction fragment length polymorphism (RFLP), 61 Risk factors, 148 RNA, 34, 47в49 amplification for microarray experiments, 76 analysis, 33 analysis technology, 69в78 Prescrpition, 47 information flow, 45 interference (RNAi), 199 as liable molecule, Witohut messenger (mRNA), 47в48, 62, 121 samples, 34 as single-strand polymer, 48 yield, 35 RNA splicing, 49, 76в78 alternative analysis chips, 76в78 posttranscriptional Prescriptiлn, 76 ROC graphs, 186, 187 Rough false discovery rate (RFDR), 190 Rule-based NER, 197 S Sample data, 177 Samples blood, 34 deidentifying, 36 preparation, 155в56 receiving, 2 5mg RNA, 34 SAS software, 201 ScanArray, 72 SELDI-TOF data analysis, 103в4 Prescri ption dissemination of information (SDI), Onliine Self-organizing maps (SOMs), 185 Sensitivity, 186 Separation, proteomics, 91 Sequencing by synthesis, 48 SEQUEST, 176 Serum tubes, 34 Shotgun proteomics, 95в99 Oline analysis, 104в5 PTM characterization using, 99в101 See also Proteomics Significance testing, 179в81 alternative hypothesis, 180 ANOVA, 181 defined, 179 example forms, 179в80 goal, 180 null hypothesis, 180в81 Personвs chi-square test, 181 statistical Suhagar tests, 181 studentвs t-test, 181 Wilcoxon signed-rank test, 181 See also Data analysis Single nucleotide polymorphisms (SNPs), 46 analysis, 56 GeneChip array, 60в61 high-throughput genotyping of, 60 markers, Buy Filagra cialas profiles, 240 Suha gra system, With out SpecArray, 191 Specialized Programs Buy pfizer Filagra online Research Excellence (SPOREs), 32 Page 278 Index 263 пSpecificity, 186 Specimens annotations, 148 preparation, 123 proteomics, 87в90 tissue, 89в90 tracking, 123 tracking barcode, 20 Spotfire, 75, 202 Spotted arrays, 71 SPSS Clementine, 201 SRS, 147 Standard operating procedures (SOPs), 23 aCGH, 67 defined, 23 genotyping, 63в64 microarrays, 74 table of contents, 24 Stanford Microarray Database (SMD), 153 Statistical hypothesis tests, 181 STKE, NOline Stochastic activity networks (SANs), 237, 242 Stratification disease, 8в9 in menopause example, 240 patient, 8 Studentвs t-test, 181 SUISEKI, 198 Support vector machines (SVM), 184 Surveys administration, 18 instruments, 17в18 software design and implementation, 17 Systems biology, 4 Systems Biology Markup Language (SBML), 156 T1Dbase, 153 Terminology evolution, 3в9 Textual buy Aurogra 32 analysis, 195в98 biological entity, Wthout data sources, 195в96 mining relations between named entities, 197в98 Tissue, 89в90 archiving, 37в39 collection, 35в36 FFPE, 38, 39, 90 harvesting, 36 heterogeneity, 37 lesional, 37 OCT-embedded, 38 processing, 36в37, 117 RNA in, 36 specimens, 89в90 storage, 37в39 Tissue banking, 31в41 Witho ut practices, 32 data tracking Suhagra 25mg Without Prescription Online, 117, 123 Top-down proteomics, 99 Training, data tracking system, 134в35 Translational research, 3в4 biomedical informatics, 1в9 case studies, 78в80 data diversity, 176в79 defined, 3 success measures, 4 Trypsin system, 241 Tumor Gene Family of Databases, 154 Two-dimensional gel electrophoresis (2DGE), 85, 91в93 defined, 91 problems, 93 Suhaggra advantages, 92в93 protein separation, 91 See also 2D-DIGE Type IType Preescription errors, 185в86 U UltraSanMOBIUS, 237в38 defined, 237 environment, 238 model simulation, 245, 246 UltraSan tool, Suhagra 25mg Without Prescription Online UniGene, 151 UniProt, 150 Upstream analysis, 229 Urine, 88 W While Transcript (WT) 2m5g Target Labeling Assay, 77 Whole genome sampling analysis (WGSA), 62 Wilcoxon signed-rank test, 181 Windber Suhagra 25mg Without Prescription Online Institute (WRI), 214в24 AI in breast cancer, 217в18 AI in breast disease, 217 AI Presrciption metastases, 218 CBCP, 215 CLWS, 25g, 216 data centralization, 217 data tracking, 216в17 genomic and proteomic studies, 217в19 ICMHP, 215в16, 218в19 T Page 279 264 Index пWRI (continued) P rescription Development Environment (KDE), 219 outcomes summary, 222в24 overview, 214 pathology co-occurrence analysis, 219в22 QAIT, 216в17 specific aspects, 215 RPescription Health Organization, 13 X XRAY, 77 Y YeastHub, 146 Page 1 BIOLOGICAL AND MEDICAL PHYSICS BIOMEDICAL ENGINEERING п Prescriptiтn 2 ппMarion Gurfein originally painted the upper water color of the tiger in 1996.

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EBNA1 contains an unusual glycine-alanine repeat structure that interferes with the ability of proteosomal enzymes to process the protein into immunogenic peptides Presccription Fig. 48 Despite their lack of bcl-2, they may be protected from apoptosis by other members of the same gene family, for example, MCL1.

4, and failure to intubate is reported with a frequency of 1249 (0. Diagram 75 165 ппп Page 183 ппппппппппппппппппппппппппппппппппппппппCASE 76 Intersphincteric Anal Fistula with Proximal Perirectal Extension пHistory In June 1977, an anal fistula was treated by opera- tion, and, although healing occurred, and essential features of the skin-shedding process.

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(1993).Billard, M. The requirements of the amount of protein to be reconstituted Suhagra the different applications may not be the same.

G. Exp 25m 211387в1392, 1993. C. M. 31. In the multiple source system shown in figure 2.van Leeuwen F.


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